GDC-0068(RG7440)

Product information

$92.40

Description

Description

GDC-0068 (RG7440 or Ipatasertib) is a novel, ATP-competitive Akt1/2/3 inhibitor with IC50 values of 5 nM, 18 nM and 8 nM, respectively. GDC-0068 selectively inhibits cell cycle progression and viability of cancer cell lines driven by PI3K/Akt signaling pathway, including those with defects of the tumor suppressor PTEN, oncogenic mutations in PIK3CA, and amplification of HER2. GDC-0068 blocks the phosphorylation of multiple downstream targets of Akt in human cancer cell lines.

Overview

Overview

Powder; no buffer, Souce: chemical synthesis, Buffer: Powder; no buffer

Additional details

Downloads

Downloads

http://www.ubpbio.com/temp/F6170%20F6171_GDC-0068%20(RG7440,%20Ipatasertib)_Datasheet.pdf

SKU

UBP-F6170

Manufacturer Part Number

F6170

UOM

5 mg