MLN4924
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$80.85
Description
Description
MLN4924 is a cell-permeable and potent inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4.7 nM. At 1 - 3 uM, MLN4924 potently inhibits the activities of Cullin-based E3 ubiquitin ligases in cells as neddylation of Cullin proteins is required for activating these ubiquitin ligases.
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